Anaplastic thyroid cancer cells upregulate mitochondrial one-carbon metabolism to meet purine demand, eliciting a critical targetable vulnerability
Adam Sugarman, Do Luong Huynh, Aidin Shabro, Antonio Di Cristofano
Topics & Concepts
Downregulation and upregulationAnaplastic thyroid cancerPurine metabolismGlycineCancer researchCell growthBiologyNucleotide salvagePurineEnzymeCell biologyCancerBiochemistryThyroid cancerGeneNucleotideGeneticsAmino acidRNA modifications and cancerUbiquitin and proteasome pathwaysCancer-related Molecular Pathways