Synthesis of Fluoro‐, Monofluoromethyl‐, Difluoromethyl‐, and Trifluoromethyl‐Substituted Three‐Membered Rings
Jonathan Decaens, Samuel Couve‐Bonnaire, André B. Charette, Thomas Poisson, Philippe Jubault
Abstract
This Minireview describes recent advances toward the synthesis of fluoro-, monofluoromethyl-, difluoromethyl-, and trifluoromethyl-substituted three-membered rings such as cyclopropanes, aziridines, epoxides, episulfides, cyclopropenes, and 2 H-azirines. The main synthetic methodologies since 2016 for cyclopropanes and since 2010 for the other three-membered rings are reported.
Topics & Concepts
TrifluoromethylChemistryRing (chemistry)StereochemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions