Targeting the kinase insert loop of PERK selectively modulates PERK signaling without systemic toxicity in mice
Daniel T. Hughes, Mark Halliday, Heather Smith, Nicholas Verity, Colin Molloy, Helois Radford, Adrian J. Butcher, Giovanna R. Mallucci
Abstract
to partially down-regulate PERK-eIF2α signaling while avoiding widespread ISR inhibition may be a safe therapeutic approach in neurodegenerative disease.
Topics & Concepts
ToxicityKinaseCell biologyProtein kinase ASignal transductionInsert (composites)BiologyPharmacologyMedicineInternal medicineMechanical engineeringEngineeringPrion Diseases and Protein MisfoldingCellular transport and secretionMicrotubule and mitosis dynamics