Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid
María Paz Beyer, Luis A. Videla, Camila Farías, Rodrigo Valenzuela
Abstract
-3, DHA) is the precursor of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families which have been considered therapeutic bioactive compounds for human health. Growing evidence indicates that DHA and SPMs are beneficial strategies in the amelioration, regulation, and duration of inflammatory processes through different biological actions. The present review discusses the reported therapeutic benefits of SPMs on various diseases and their potential clinical applications.
Topics & Concepts
Docosahexaenoic acidLipid signalingHuman healthMedicineComputational biologyChemistryBioinformaticsInflammationPolyunsaturated fatty acidBiologyBiochemistryFatty acidImmunologyEnvironmental healthFatty Acid Research and HealthNatural Products and Biological ResearchEicosanoids and Hypertension Pharmacology