Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells
Nicholas A.J. Dawson, Isaac Rosado‐Sánchez, Gherman Novakovsky, Vivian Fung, Qing Huang, Emma McIver, Grace Y. Sun, Jana Gillies, Madeleine Speck, Paul C. Orban, Majid Mojibian, Megan K. Levings
Abstract
Comparison of 10 co-receptor variant CARs revealed a requirement for CD28wt for optimal suppression by human regulatory T cells.
Topics & Concepts
Chimeric antigen receptorReceptorCell biologyCo-receptorSignal transductionBiologyChemistryImmunologyImmune systemT cellGeneticsCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology