Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia
Wayne A. Cabral, Nadja Fratzl‐Zelman, MaryAnn Weis, Joseph E. Perosky, Adrienne Alimasa, R.C. Harris, Heeseog Kang, Elena Makareeva, Aileen M. Barnes, Paul Roschger, Sergey Leikin, Klaus Klaushofer, Antonella Forlino, Peter S. Backlund, David R. Eyre, Kenneth M. Kozloff, Joan C. Marini
Topics & Concepts
Osteogenesis imperfectaHydroxylationType I collagenChemistryMutantCollagen, type I, alpha 1DysplasiaWild typeCartilage oligomeric matrix proteinCartilageEndocrinologyCell biologyBiochemistryInternal medicineExtracellular matrixAnatomyBiologyEnzymePathologyMedicineGeneOsteoarthritisAlternative medicineConnective tissue disorders researchBone and Dental Protein StudiesCancer-related gene regulation