Antimicrobial gel with silver vanadate and silver nanoparticles: antifungal and physicochemical evaluation
João Marcos Carvalho Silva, Ana Beatriz Vilela Teixeira, Marco Antônio Schiavon, Andréa Cândido dos Reis
Abstract
Aim: To develop a β-AgVO3 gel and evaluate its physicochemical stability and antifungal activity against Candida albicans.Materials & methods: The gel was prepared from the minimum inhibitory concentration (MIC) of β-AgVO3. The physicochemical stability was evaluated by centrifugation, accelerated stability (AS), storage (St), pH, syringability, viscosity and spreadability tests and antifungal activity by the agar diffusion.Results: The MIC was 62.5 μg/ml. After centrifugation, AS and St gels showed physicochemical stability. Lower viscosity and higher spreadability were observed for the higher β-AgVO3 concentration and the minimum force for extrusion was similar for all groups. Antifungal effect was observed only for the β-AgVO3 gel with 20xMIC.Conclusion: The β-AgVO3 gel showed physicochemical stability and antifungal activity.