A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment
Lindsay B. Alcaraz, Aude Mallavialle, Timothée David, Danielle Derocq, Frédéric Delolme, Cindy Dieryckx, Caroline Mollévi, Florence Boissière‐Michot, Joëlle Simony-Lafontaine, Stanislas du Manoir, Pitter F. Huesgen, Christopher M. Overall, Sophie Tartare‐Deckert, William Jacot, Thierry Chardès, Séverine Guiu, Pascal Roger, Thomas Reinheckel, Catherine Moali, Emmanuelle Liaudet‐Coopman
Abstract
Our study establishes a novel crosstalk between proteases and matricellular proteins in the tumor microenvironment through limited SPARC proteolysis, revealing a novel targetable 9-kDa bioactive SPARC fragment for new TNBC treatments. Our study will pave the way for the development of strategies for targeting bioactive fragments from matricellular proteins in TNBC.