NF-κB and Keap1 Interaction Represses Nrf2-Mediated Antioxidant Response in Rabbit Hemorrhagic Disease Virus Infection
Bo Hu, Houjun Wei, Yanhua Song, Mengmeng Chen, Zhiyu Fan, Rulong Qiu, Weifeng Zhu, Weizhong Xu, Fang Wang
Abstract
Recent studies have reported that rabbit hemorrhagic disease virus (RHDV) infection reduced Nrf2-related antioxidant function. However, the regulatory mechanisms underlying this process remain unclear. The current study showed that the NF-κB p50 subunit partners with Keap1 to form the Keap1-NF-κB complex, which plays a key role in the inhibition of Nrf2 transcriptional activity. More importantly, upregulated Nrf2 activity delayed the death of RHDV-infected rabbits, strongly indicating the importance of oxidative damage during RHDV infection. These findings may provide novel insights into the pathogenesis of RHDV.
Topics & Concepts
BiologyKEAP1VirologyNF-κBVirusNFKB1DiseaseImmunologyCancer researchInflammationTranscription factorGeneticsInternal medicineGeneMedicineGenomics, phytochemicals, and oxidative stress