Discovery of imidazo[1,2-<i>b</i>]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma
Desmond Akwata, Allison L. Kempen, Jones Lamptey, Neetu Dayal, Nickolas R. Brauer, Herman O. Sintim
Abstract
values as low as 30 nM. These compounds have the potential to be translated into anti-MM therapeutics.
Topics & Concepts
PyridazineChemistryPiperazineMultiple myelomaIC50BortezomibKinaseProteasomeCancer researchPharmacologyMorpholineCD38MedicineIn vitroBiochemistryStereochemistryBiologyImmunologyCell biologyCD34Stem cellMedicinal chemistryMultiple Myeloma Research and TreatmentsQuinazolinone synthesis and applicationsCancer Mechanisms and Therapy