Cascade cyclization for the synthesis of indolo[2,1-α]isoquinoline derivatives <i>via</i> visible-light-induced halogen-atom-transfer (XAT) and hydrogen-atom-transfer (HAT)
Na Ma, Lin Guo, Zhengjia Shen, Dan Qi, Chao Yang, Wujiong Xia
Abstract
either the halogen-atom-transfer (XAT) or the hydrogen-atom-transfer (HAT) process, furnishing the desired indolo[2,1-α]isoquinoline derivatives in good to moderate yields. This protocol features broad substrate scope and good functional group tolerance under mild conditions.
Topics & Concepts
IsoquinolineHydrogen atomHalogenChemistryAtom (system on chip)CascadePhotochemistryStereochemistryOrganic chemistryComputer scienceGroup (periodic table)AlkylChromatographyEmbedded systemRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions