Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons
M Beatriz, Ricardo J. Rodrigues, Rita Vilaça, Conceição Egas, Paulo S. Pinheiro, George Q. Daley, Thorsten M. Schlaeger, Nuno Raimundo, A. Cristina Rego, Carla Lopes
Abstract
The EV-mediated reversal of the abnormal GABAergic phenotype in HD-derived neurons reinforces the potential role of EV-miRNAs on synapse regulation.
Topics & Concepts
GABAergicBiologySynapseNeuroscienceInduced pluripotent stem cellNeurotransmissionCell biologyInhibitory postsynaptic potentialSynaptic vesicleExtracellular vesiclesReceptorVesicleEmbryonic stem cellGeneGeneticsMembraneGenetic Neurodegenerative DiseasesExtracellular vesicles in diseaseRNA Research and Splicing