Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo
Xing Chen, Yaoyao Yan, Juncheng Du, Xiaobao Shen, Chuanbiao He, Haitao Pan, Jun Zhu, Xinhua Liu
Topics & Concepts
ChemistryIn vivoStructure–activity relationshipCathepsinEnzyme inhibitorPharmacologyEx vivoStereochemistryCathepsin GIC50Covalent bondSerineProteasesCathepsin BEnzymeBiochemistryIn vitroBiologyOrganic chemistryBiotechnologyProtease and Inhibitor MechanismsNeutrophil, Myeloperoxidase and Oxidative MechanismsS100 Proteins and Annexins