Obstructive sleep apnea syndrome and causal relationship with female breast cancer: a mendelian randomization study
Xiaoling Gao, Zhi-Mei Jia, Fangfang Zhao, Dong‐Dong An, Bei Wang, Erjing Cheng, Yan Chen, Jiannan Gong, Dai Liu, Ya‐Qiong Huang, Jiaojiao Yang, Shujuan Wang
Abstract
). Replication in the Asian population of the BCAC study also supported our results (IVW OR, 1.33 for BC risk per log-odds increment in OSAS risk, 95% CI = 1.13-1.56; P = 0.0006). Sensitivity analyses confirmed the robustness of our findings. We provide novel evidence that genetically determined higher risk of OSAS has a causal effect on higher risk of BC. Further studies focused on the mechanisms of the relationship between OSAS and breast carcinogenesis are needed.
Topics & Concepts
Mendelian randomizationMedicineObstructive sleep apneaOdds ratioBreast cancerInternal medicineObservational studyPopulationOncologyCancerGeneticsGenotypeBiologyEnvironmental healthGenetic variantsGeneObstructive Sleep Apnea ResearchHead and Neck Cancer StudiesTracheal and airway disorders