A Review of Adropin as the Medium of Dialogue between Energy Regulation and Immune Regulation
Shuyu Zhang, Qingquan Chen, Xu-Chen Lin, Min Chen, Qicai Liu
Abstract
Adropin is a secretory protein encoded by the energy balance gene and is closely associated with regulation of energy metabolism and insulin resistance. The clinical findings demonstrated its decreased expression in various inflammatory diseases, its negative correlation with the expression levels of inflammatory cytokines, and its potential anti-inflammatory effects. We speculate that adropin plays a pivotal regulatory role in immune cells and inflammatory factors. In this study, we reviewed the advances in researches concentrated on immunological effects of adropin.
Topics & Concepts
Immune systemEnergy metabolismInflammationRegulation of gene expressionBiologyGene expressionProinflammatory cytokineImmunologyInsulin resistanceCell biologyMetabolic regulationGeneMetabolismInsulinGeneticsEndocrinologyAdipose Tissue and MetabolismDiet and metabolism studiesMitochondrial Function and Pathology