Chemometric optimization of salting-out assisted liquid–liquid extraction (SALLE) combined with LC-MS/MS for the analysis of carvedilol enantiomers in human plasma: Application to clinical pharmacokinetics
Marcella Gallati Pavan, Priscila Akemi Yamamoto, Rodrigo Moreira da Silva, Wilson Salgado, José Dos Santos, Rafael Kemp, Ajith Kumar Sankarankutty, Natália Valadares de Moraes, Cristiane de Gaitani
Topics & Concepts
ChemistryChromatographyCarvedilolDiethylaminePharmacokineticsEnantiomerFactorial experimentExtraction (chemistry)Liquid chromatography–mass spectrometryHigh-performance liquid chromatographyElectrospray ionizationMass spectrometryPharmacologyStereochemistryMathematicsStatisticsHeart failureInternal medicineMedicineOrganic chemistryAnalytical Methods in PharmaceuticalsAntibiotics Pharmacokinetics and EfficacyBlood Pressure and Hypertension Studies