HilD, HilC, and RtsA Form Homodimers and Heterodimers To Regulate Expression of the <i>Salmonella</i> Pathogenicity Island I Type III Secretion System
Koh-Eun Narm, Marinos Kalafatis, James M. Slauch
Abstract
to both cause gastroenteritis and initiate serious systemic disease. The system responds to numerous environmental signals in the intestine, integrating this information via a complex regulatory network. Here, we show that the primary regulatory proteins in the network function as both homodimers and heterodimers, providing information regarding both regulation of virulence in this important pathogen and general signal integration to control gene expression.
Topics & Concepts
BiologyVirulenceSecretionPathogenicity islandType three secretion systemSalmonellaVirulence factorCell biologyPathogenFunction (biology)GeneMicrobiologyRegulation of gene expressionGeneticsBacteriaBiochemistrySalmonella and Campylobacter epidemiologyEscherichia coli research studiesViral gastroenteritis research and epidemiology