Comparison of busulfan and total body irradiation conditioning on hematopoietic clonal dynamics following lentiviral gene transfer in rhesus macaques
Diana M. Abraham, Richard Lozano, Xavi Guitart, Jialiu A. Liang, Ryland D. Mortlock, Diego A. Espinoza, Xing Fan, Allen E. Krouse, Aylin Bonifacino, So Gun Hong, Komudi Singh, John F. Tisdale, Chuanfeng Wu, Cynthia E. Dunbar
Abstract
NK-biased clonal expansion compared with TBI animals. Therefore, busulfan conditioning regimens can variably impact the marrow niche, resulting in differences in clonal patterns with implications for HSPC gene therapies.
Topics & Concepts
BusulfanTotal body irradiationHaematopoiesisVirologyBiologyGene transferGeneHematopoietic stem cell transplantationGeneticsStem cellCyclophosphamideChemotherapyVirus-based gene therapy researchViral gastroenteritis research and epidemiologyXenotransplantation and immune response