Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a <i>Drosophila</i> Model of Alzheimer’s Disease
Annachiara Gandini, Ana Elisa Gonçalves, Silvia Strocchi, Claudia Albertini, Jana Janočková, Anna Tramarin, Daniela Grifoni, Eleonora Poeta, Ondřej Soukup, Diego Muñoz‐Torrero, Barbara Monti, Raimon Sabaté, Manuela Bartolini, Giuseppe Legname, María Laura Bolognesi
Abstract
deserve further attention as hits for dual Aβ/Tau aggregation inhibition in AD.
Topics & Concepts
Drosophila melanogasterDrug discoveryIn vivoPharmacologyBiologyChemistryComputational biologyMedicineBiochemistryGeneticsGeneCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsComputational Drug Discovery Methods