Ultrathin 2D Cu-Porphyrin MOF Nanosheet Loaded Fe<sub>3</sub>O<sub>4</sub> Nanoparticles As a Multifunctional Nanoplatform for Synergetic Chemodynamic and Photodynamic Therapy Independent of O<sub>2</sub>
Jingjing Jiao, Huan Yang, Huan Yang, Xuemeng Zhou, Kangkang Huang, Xue Zhang, Hong Yang, Hong Yang, Wei Gong, Shiping Yang
Abstract
In this study, we developed a multifunctional nanoplatform to address the limitations of strictly acidic pH for the Fenton reaction involving Fe 3 O 4 and the low efficiency of mono treatments. The hybrid material, Fe 3 O 4 @Cu-TCPP, was assembled through hydrophobic interactions of polyvinylpyrrolidone (PVP) coated on its surface. The efficiency of the Fenton reaction using Fe 3 O 4 was significantly enhanced by the photo-Fenton process in the presence of Cu-TCPP. The generation of hydroxyl radicals by Fe 3 O 4 @Cu-TCPP was markedly increased under laser irradiation (λ = 660 nm) in solution. Fe 3 O 4 @Cu-TCPP demonstrated a robust ability to produce reactive oxygen species through chemodynamic and photodynamic processes independent of that of O 2 . In vivo experimental results indicated that Fe 3 O 4 @Cu-TCPP facilitated T 2 -weighted magnetic resonance imaging-mediated synergistic chemodynamic and photodynamic therapies in a 4T1 mouse model.