Exploration of nitrogen heterocycle scaffolds for the development of potent human neutrophil elastase inhibitors
Niccolò Cantini, Аndrei I. Khlebnikov, Letizia Crocetti, Igor A. Schepetkin, Giuseppe Floresta, Gabriella Guerrini, Claudia Vergelli, Gianluca Bartolucci, Mark T. Quinn, Maria Paola Giovannoni
Topics & Concepts
ChemistryElastaseIn silicoEnzymeBiochemistryNeutrophil elastaseProteaseBiological activityIn vitroIC50Combinatorial chemistryStereochemistryInternal medicineMedicineInflammationGeneProtease and Inhibitor MechanismsPeptidase Inhibition and AnalysisSignaling Pathways in Disease