A stable liver-specific urate oxidase gene knockout hyperuricemia mouse model finds activated hepatic de novo purine biosynthesis and urate nephropathy

Lei Pang, Ningning Liang, Changgui Li, Tony R. Merriman, Hui Zhang, Fei Yan, Wenyan Sun, Rui Li, Xiaomei Xue, Zhen Liu, Can Wang, Xiaoyu Cheng, Shiting Chen, Huiyong Yin, Nicola Dalbeth, Xuan Yuan