BMSC exosomes deliver JKAP to restore Th17/Treg balance via AKT/ERK, alleviating rheumatoid arthritis
Fang-Tian Xu, Ling Yu, Heng Wei, Lingzhang Meng, Dong Yin, Zhonghong Lai, Yuying Huang, Xiao Huang, Hai-Ye Li, Qin-Wen Luo, Jian Song, Qiang Tang, Hong-Mian Li
Abstract
T cell proliferation and RA-FLS inflammation, reversed by AKT/ERK inhibition. In collagen-induced arthritis mice, exosomes alleviated symptoms and restored Th17/Treg balance, whereas JKAP knockdown exacerbated arthritis and disrupted balance. JKAP-overexpressing exosomes showed opposite effects. Thus, BMSC exosomes mitigate RA by delivering JKAP to restore immune balance via AKT/ERK pathways.
Topics & Concepts
MicrovesiclesProtein kinase BMAPK/ERK pathwayInflammationMesenchymal stem cellImmunologyCancer researchExosomeArthritisMedicineGene knockdownRheumatoid arthritisCell biologySignal transductionChemistryBiologyApoptosismicroRNAPathologyBiochemistryGeneExtracellular vesicles in diseaseImmunotherapy and Immune ResponsesAutoimmune and Inflammatory Disorders Research