RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs
Seung Hyuk Choi, Mathieu N. Flamand, Bei Liu, Huanyu Zhu, Meghan Hu, Melanie Wang, Jonathon Sewell, Christopher L. Holley, Hashim M. Al‐Hashimi, Kate D. Meyer
Abstract
A-independent mechanisms. Finally, we find that RBM45 is necessary for neuroblastoma cell differentiation and that its depletion impacts the expression of genes involved in several neurodevelopmental signaling pathways. Altogether, our findings show a role for RBM45 in controlling mRNA processing and neuronal differentiation, mediated in part by the recognition of methylated RNA.
Topics & Concepts
RNA splicingMessenger RNABiologyRNA-binding proteinCell biologyAlternative splicingRNAPrecursor mRNAGene expressionGeneGeneticsRNA modifications and cancerRNA Research and SplicingCancer-related gene regulation