Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation
Donge Tang, Xiaohui Liu, Kezhi Chen, Zhipeng Li, Yong Dai, Jiake Xu, Huan‐Tian Zhang, Xuejuan Gao, Langxia Liu
Abstract
bone resorption. Interactomic study has revealed β-actin as the major interacting partner of the cytoplasmic PCNA, suggesting that cytoplasmic PCNA might play a critical role in the differentiation of osteoclast through regulation of actin-cytoskeleton remodeling. Taken together, our results demonstrate the critical role of cytoplasmic PCNA during the process of osteoclast differentiation, and provided a potential therapeutic target for treatment of osteoclast-related bone diseases.
Topics & Concepts
OsteoclastProliferating cell nuclear antigenActinCell biologyCytoplasmChemistryBiologyCell growthBiochemistryIn vitroBone Metabolism and DiseasesBone health and treatmentsRadiopharmaceutical Chemistry and Applications