Cortical bone stem cell-derived exosomes’ therapeutic effect on myocardial ischemia-reperfusion and cardiac remodeling
Giana Schena, Emma K. Murray, Alycia N. Hildebrand, Alaina L. Headrick, Yijun Yang, Keith A. Koch, Hajime Kubo, Deborah Eaton, Jaslyn Johnson, Remus M. Berretta, Sadia Mohsin, Raj Kishore, Timothy A. McKinsey, John W. Elrod, Steven R. Houser
Abstract
Our work is noteworthy due to the identification of factors within stem cell-derived exosomes (dEXOs) that alter fibroblast activation through the hereto-unknown mechanism of decreasing small nucleolar RNA (snoRNA) signaling within cardiac fibroblasts. The study also shows that the injection of stem cells or a stem-cell-derived exosome therapy at the onset of reperfusion elicits cardioprotection, emphasizing the importance of early treatment in the post-ischemia-reperfusion (I/R) wounded heart.
Topics & Concepts
Heart failureMedicineMyocardial infarctionIschemiaCardiac function curveStem cellVentricular remodelingFibrosisCardiac fibrosisCardiologyInternal medicineCell biologyBiologyExtracellular vesicles in diseaseCardiac Fibrosis and RemodelingTissue Engineering and Regenerative Medicine