Targeted delivery of oligonucleotides using multivalent protein–carbohydrate interactions
Vajinder Kumar, W. Bruce Turnbull
Abstract
-acetylgalactosamine (GalNAc) ligand. This ligand enables efficient uptake of the nucleic acid by the asialoglycoprotein receptor (ASGP-R) on hepatocytes. Synthetic multivalent ligands for ASGP-R were among the first 'cluster glycosides' developed at the birth of multivalent glycoscience around 40 years ago. In this review we trace the history of 'GalNAc targeting' from early academic studies to current pharmaceuticals and consider what other opportunities could follow the success of this delivery technology.
Topics & Concepts
OligonucleotideChemistryCarbohydrateNanotechnologyComputational biologyBiochemistryDNABiologyMaterials scienceGlycosylation and Glycoproteins ResearchRNA Interference and Gene DeliveryPancreatic function and diabetes