<i>Dendrobium fimbriatum</i> Hook polysaccharide ameliorates dextran-sodium-sulfate-induced colitis in mice <i>via</i> improving intestinal barrier function, modulating intestinal microbiota, and reducing oxidative stress and inflammatory responses
Yujing Wang, Qiang-Ming Li, Xue‐Qiang Zha, Jian‐Ping Luo
Abstract
in colitis mice. Notably, cDFPW1 significantly restored the homeostasis of Th17/regulatory T (Treg) cells and the expression of specific cytokines. Western blotting of colon tissues showed that cDFPW1 markedly up-regulated the expression of Nrf2 and inhibited the phosphorylation of NF-κB signaling. These results indicated that cDFPW1 possesses the potential of improving UC and its effect on palliating colitis may be connected with the regulation of Nrf2/NF-κB signaling.
Topics & Concepts
ColitisBarrier functionUlcerative colitisInflammatory bowel diseaseOxidative stressChemistryDendrobiumPolysaccharideMicrobiologyImmunologyBiologyBiochemistryCell biologyMedicineInternal medicineDiseaseBotanyGut microbiota and healthBiological and pharmacological studies of plantsInflammatory Bowel Disease