Colorectal cancer: epidemiology, carcinogenesis, molecular subtypes and cellular mechanisms of therapy resistance (analytical review)
P. E. Maksimova, E. P. Golubinskaya, B. D. Seferov, Evgeniya Y. Zyablitskaya
Abstract
This article analyzes the statistical data on colorectal cancer in Russia and in the world, including incidence, mortality and survival. The main pathways of colorectal cancer carcinogenesis, molecular subtypes and their influence on the difference in lesions of the proximal and distal large intestine are presented. The paper provides an overview of the leading chemotherapy agents and targeted therapy in colorectal cancer, as well as the main reasons for the development of therapeutic resistance, including changes in the cellular microenvironment of the tumor.
Topics & Concepts
Colorectal cancerCarcinogenesisCancerOncologyMedicineCancer researchMouse model of colorectal and intestinal cancerEpidemiologyTumor microenvironmentTargeted therapyChemotherapyIncidence (geometry)Internal medicineBioinformaticsBiologyPhysicsOpticsColorectal Cancer Treatments and StudiesGastric Cancer Management and OutcomesColorectal Cancer Screening and Detection