Role of the complement cascade in the biological fate of liposomes in rodents
Iara Maíra de Oliveira Viana, P. Grenier, Joan Defrêne, Frédéric Barabé, Eliana Martins Lima, Nicolas Bertrand
Abstract
), animals treated with CVF had slightly higher levels of circulating liposomes, especially during the 24 hours pharmacokinetic studies. The complement cascade seems to govern the uptake of non-PEGylated liposomes by splenic B cells. Altogether, these results suggest that although PEGylated and non-PEGylated liposomes can activate complement, the impact of this cascade on their circulation time is minor and mostly perceivable at later phases of distribution. This work enlightens biological pathways responsible for in vivo clearance of liposomes and will help in orienting future research in elucidating the nano-bio interface.
Topics & Concepts
LiposomeComplement (music)CascadeComplement systemCirculation (fluid dynamics)KineticsChemistryBiophysicsBiologyImmunologyBiochemistryAntibodyPhysicsChromatographyQuantum mechanicsComplementationPhenotypeGeneThermodynamicsNanoparticle-Based Drug DeliveryComplement system in diseasesPhagocytosis and Immune Regulation