HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma
Xuejing Zou, Dongyan Zhang, Yang Song, Shanshan Liu, Long Qian, Liheng Yao, Wenwen Li, Zhijiao Duan, Dehua Wu, Li Liu
Abstract
Our findings illustrate a crucial role for HRG in suppressing HCC via inclining TNFR1 to a pro-apoptotic cellular phenotype. Restoring HRG expression in HCC tissues might be a promising pharmacological approach to blocking tumor progression by shifting cellular fate from cell survival to apoptosis.
Topics & Concepts
Tumor necrosis factor receptor 1ApoptosisDownregulation and upregulationCancer researchCell biologySignal transductionCell cultureHepatocellular carcinomaBiologyChemistryBiochemistryGeneTumor necrosis factor receptorGeneticsinterferon and immune responsesUbiquitin and proteasome pathwaysNF-κB Signaling Pathways