Real-time monitoring of abnormal mitochondrial viscosity in glioblastoma with a novel mitochondria-targeting fluorescent probe
Qing Zhang, Wei Liu, Ling Jiang, Yanjun He, WU Chang-jian, Shen‐Zhen Ren, Baozhong Wang, Li Liu, Hai‐Liang Zhu, Zhong‐Chang Wang
Abstract
orthotopic tumor-bearing models demonstrated that the probe ZVGQ exhibited exceptional tissue penetration depth and the ability to penetrate the BBB. The probe ZVGQ not only successfully visualizes abnormal mitochondrial viscosity changes, but also provides a practical and feasible tool for real-time imaging and clinical diagnosis of glioblastoma.
Topics & Concepts
MitochondrionBiophysicsGlioblastomaFluorescenceChemistryIn vitroIn vivoBiologyCancer researchBiochemistryQuantum mechanicsBiotechnologyPhysicsMolecular Sensors and Ion DetectionNanoplatforms for cancer theranosticsSupramolecular Chemistry and Complexes