Pd-Catalyzed Selective B(6)–H Phosphorization of <i>nido</i>-Carboranes via Cascade Deboronation/B–H Activation from <i>closo</i>-Carboranes
Chaofan Sun, Ju‐You Lu, Jian Lu
Abstract
Efficient Pd-catalyzed regioselective B(6)–H phosphorization of nido-carboranes via cascade deboronation/B–H activation of readily available C-substituted o-carboranes with various phosphines using 3-methylpyridine or isoquinoline as a directing group in combination with pyridine ligands has been developed, affording unprecedented B(6)-phosphinated nido-carborane derivatives with high selectivity in a simple one-pot process.
Topics & Concepts
ChemistryIsoquinolineCatalysisRegioselectivityCarboraneSelectivityPyridineMedicinal chemistryCascadeCombinatorial chemistryOrganic chemistryChromatographyBoron Compounds in ChemistryRadiopharmaceutical Chemistry and ApplicationsBone health and treatments