Ketone ester ingestion impairs exercise performance without impacting cognitive function or circulating EPO during acute hypoxic exposure
Myrthe Stalmans, Domen Tominec, Wout Lauriks, Ruben Robberechts, Monique Ramaekers, Tadej Debevec, Chiel Poffé
Abstract
This study is the first to show that KE ingestion impairs exercise performance in hypoxia, at least when KE does not alleviate hypoxemia. Despite a subsequent, progressive increase in oxygenation upon KE after 3-4 h, this does not protect against hypoxia-induced cognitive declines. Although studies in normoxia show potential of KE to increase blood [erythropoietin], we identified that KE ingestion fails to augment the increase in blood [erythropoietin] through hypoxic exposure and exercise.
Topics & Concepts
HypoxemiaHypoxia (environmental)OxygenationIngestionMedicineErythropoietinInternal medicineEffects of high altitude on humansEndocrinologyOxygenChemistryOrganic chemistryAnatomyHigh Altitude and HypoxiaDiet and metabolism studiesMetabolomics and Mass Spectrometry Studies