Mechanism of darunavir binding to monomeric HIV-1 protease: a step forward in the rational design of dimerization inhibitors
Mohd Ahsan, Chinmai Pindi, Sanjib Senapati
Abstract
value in the picomolar range. The residue-level information extracted from this study could accelerate the structure-based drug designing approaches targeting HIVPR dimerization.
Topics & Concepts
DarunavirChemistryRational designDrug designHIV-1 proteaseMonomerProteaseStereochemistryPlasma protein bindingDrugBinding siteDocking (animal)Combinatorial chemistryCooperative bindingBiophysicsHuman immunodeficiency virus (HIV)BiochemistryEnzymeBiologyNanotechnologyVirologyPharmacologyAntiretroviral therapyMaterials scienceMedicineOrganic chemistryPolymerNursingViral loadHIV/AIDS drug development and treatmentHIV Research and TreatmentHIV/AIDS Research and Interventions