Early Virus Clearance and Delayed Antibody Response in a Case of Coronavirus Disease 2019 (COVID-19) With a History of Coinfection With Human Immunodeficiency Virus Type 1 and Hepatitis C Virus
Juanjuan Zhao, Xuejiao Liao, Haiyan Wang, Lanlan Wei, Mingzhao Xing, Lei Liu, Zheng Zhang
Abstract
The effect of host immune status on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unknown. Here, we report the first case of coronavirus disease 2019 (COVID-19) with human immunodeficiency virus type 1 (HIV-1)/hepatitis C virus coinfection, who showed a persistently negative SARS-CoV-2 RNA test but delayed antibody response in the plasma. This case highlights the influence of HIV-1-induced immune dysfunction on early SARS-CoV-2 clearance.
Topics & Concepts
VirologyCoinfectionVirusCoronavirusHepatitis C virusHepatitis a virusCoronavirus disease 2019 (COVID-19)MedicineDiseaseBiologyInfectious disease (medical specialty)PathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesCOVID-19 Impact on Reproduction