Intracellular bacteriolysis contributes to pathogenicity of <i>Staphylococcus aureus</i> by exacerbating AIM2-mediated inflammation and necroptosis
Shiyuan Feng, Yongjun Yang, Zhenzhen Liu, Wei Chen, Chongtao Du, Guiqiu Hu, Shui-Xing Yu, Peixuan Song, Jinfeng Miao
Abstract
sacrifices the minority to trigger a limited necroptosis, thereby releasing signals from dead cells to inhibit apoptosis and other anti-inflammatory cascades of live cells, eventually surviving within host cells and establishing infection.
Topics & Concepts
PyroptosisNecroptosisAIM2BiologyInflammasomeProgrammed cell deathStaphylococcus aureusInflammationMicrobiologyIntracellularCaspase 1PopulationIntracellular parasiteCell biologyApoptosisImmunologyMedicineBacteriaEnvironmental healthGeneticsBiochemistryInflammasome and immune disordersStreptococcal Infections and TreatmentsCell death mechanisms and regulation