Litcius/Paper detail

A cancer graph: a lung cancer property graph database in Neo4j

David Tuck

2022BMC Research Notes12 citationsDOIOpen Access PDF

Abstract

OBJECTIVES: A novel graph data model of non-small cell lung cancer clinical and genomic data has been constructed with two aims: (1) provide a suitable model for facilitating graph analytics within the Neo4j framework or through tools which can interact through existing Neo4j APIs; and (2) provide a base model extensible to other cancer types and additional datasets such as those derived from electronic health records and other real world sources. DATA DESCRIPTION: Clinical and genomic data integrated with a novel property graph database schema from publicly available datasets and analyses based on The Cancer Genome Atlas lung cancer datasets augmented by with subgraphs patient-patient social network from similarity and correlation as well as individual based biological networks.

Topics & Concepts

Graph databaseComputer scienceSchema (genetic algorithms)GraphLung cancerData miningInformation retrievalTheoretical computer scienceMedicineInternal medicineBioinformatics and Genomic NetworksGene expression and cancer classificationEpigenetics and DNA Methylation