Antidrug antibodies against the polyethylene glycol moiety inhibit the procoagulant activity of therapeutic polyethylene glycolated factor VIII
Behnaz Pezeshkpoor, Nadja Sereda, Ann‐Cristin Berkemeier, Isabell Matuschek, Nadine Schwarz, Peter L. Turecek, Silvia Horneff, Claudia Klein, Georg Goldmann, Natascha Marquardt, T. Albert, Jens Müller, Johannes Oldenburg
Topics & Concepts
AntibodyPEG ratioPolyethylene glycolPEGylationIsotypeChemistryImmunoassayPharmacokineticsPharmacologyMolecular biologyMedicineMonoclonal antibodyImmunologyBiochemistryBiologyEconomicsFinanceHemophilia Treatment and ResearchProtein purification and stabilityBlood properties and coagulation