Ni(<scp>ii</scp>), Cu(<scp>ii</scp>) and Zn(<scp>ii</scp>) complexes with the 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for cancer therapy
Lan-Shan Liao, Yin Chen, Zu‐Yu Mo, Cheng Hou, Gui‐Fa Su, Hong Liang, Zhen‐Feng Chen
Abstract
Complexes <bold>1–3</bold> display potent anticancer activity against T-24 cell by disrupting mitochondria and microtubules. Furthermore, complex <bold>1</bold> exhibits almost same tumor growth inhibition activity in T-24 xenograft mouse model as cisplatin and paclitaxel.
Topics & Concepts
ChemistryPaclitaxelMitochondrionMicrotubuleLigand (biochemistry)Cell biologyStereochemistryBiophysicsBiochemistryCancerReceptorBiologyGeneticsMetal complexes synthesis and propertiesMetal-Catalyzed Oxygenation MechanismsMagnetism in coordination complexes