A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2
Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi‐Chin Sun, Yun Chen, Baoding Zhang, Li Li, Huiling Mu, Song Ding, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huan-wei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng, Hai Jiang
Topics & Concepts
UbiquitinBiologyFusion proteinCancer researchProteolysisSKP2Programmed cell deathProtein degradationPhenotypeCell cultureHEK 293 cellsApoptosisMdm2Small moleculeCancerPeptide sequenceCancer cellCellDegradation (telecommunications)Cell biologyCell growthMolecular biologyAmino acidProtein stabilityChemistryEnzymeProteasomeProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysCAR-T cell therapy research