Pyocyanin and 1-Hydroxyphenazine Promote Anaerobic Killing of Pseudomonas aeruginosa via Single-Electron Transfer with Ferrous Iron
Jihee Lee Kang, You‐Hee Cho, Yunho Lee
Abstract
Pseudomonas aeruginosa is an opportunistic human pathogen which infects patients with burns, immunocompromised individuals, and in particular, the mucus that accumulates on the surface of the lung in cystic fibrosis (CF) patients. Phenazines as redox-active small molecules have been reported as important compounds for the control of cellular functions and virulence as well as anaerobic survival via electron shuttles.
Topics & Concepts
PyocyaninPhenazinePseudomonas aeruginosaFerrousMicrobiologyChemistryReactive oxygen speciesCatalaseSuperoxide dismutaseElectron transferVirulenceRadicalRedoxPhotochemistryAntioxidantBiochemistryBiologyBacteriaOrganic chemistryGeneQuorum sensingGeneticsBacterial biofilms and quorum sensingPlant Pathogenic Bacteria StudiesEssential Oils and Antimicrobial Activity