(DiMeIHept<sup>Cl</sup>)Pd: A Low-Load Catalyst for Solvent-Free (Melt) Amination
Volodymyr Semeniuchenko, Sepideh Sharif, Jonathan Day, Nalin Chandrasoma, William J. Pietro, Jeffrey M. Manthorpe, Wilfried M. Braje, Michael G. Organ
Abstract
, a hyper-branched N-aryl Pd NHC catalyst, has been shown to be efficient at performing amine arylation reactions in solvent-free ("melt") conditions. The highly lipophilic environment of the alkyl chains flanking the Pd center serves as lubricant to allow the complex to navigate through the paste-like environment of these mixtures. The protocol can be used on a multi-gram scale to make a variety of aniline derivatives, including substrates containing alcohol moieties.
Topics & Concepts
ChemistryAminationCatalysisSolventPalladiumOrganic chemistryPolymer chemistryAsymmetric Hydrogenation and CatalysisNanomaterials for catalytic reactionsCatalytic Cross-Coupling Reactions