AR-induced ZEB1-AS1 represents poor prognosis in cholangiocarcinoma and facilitates tumor stemness, proliferation and invasion through mediating miR-133b/HOXB8
Xingming Jiang, Jinglin Li, Weina Wang, Zengtao Hu, Canghai Guan, Yuqiao Zhao, Wenzhi Li, Yunfu Cui
Abstract
, and inhibited CCA cell migration and invasion by reversing epithelial-mesenchymal transition. For the mechanism, androgen receptor (AR) directly promoted ZEB1-AS1 expression, and further ZEB1-AS1 increased oncogene homeobox B8 (HOXB8) by sponging miR-133b. In addition, malignant phenotypes of CCA promoted by ZEB1-AS1 dysregulation were rescued separately through interfering miR-133b and HOXB8, suggesting AR/ZEB1-AS1/miR-133b/HOXB8 exerted crucial functions in tumorigenesis and progression of CCA.
Topics & Concepts
Cancer researchMedicineBiologyCholangiocarcinoma and Gallbladder Cancer StudiesCancer-related molecular mechanisms researchMicroRNA in disease regulation