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A novel cascade signal amplification strategy integrating CRISPR/Cas13a and branched hybridization chain reaction for ultra-sensitive and specific SERS detection of disease-related nucleic acids

Jingjing Zhang, Chunyuan Song, Yunfeng Zhu, Hongyu Gan, Xinyue Fang, Qian Peng, Jingrong Xiong, Chen Dong, Caiqin Han, Lianhui Wang

2022Biosensors and Bioelectronics42 citationsDOI

Topics & Concepts

Nucleic acidDetection limitPolymerase chain reactionComputational biologyNanotechnologyChemistryBiologyMaterials scienceChromatographyBiochemistryGeneAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionCRISPR and Genetic Engineering
A novel cascade signal amplification strategy integrating CRISPR/Cas13a and branched hybridization chain reaction for ultra-sensitive and specific SERS detection of disease-related nucleic acids | Litcius