Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
Yinghuan Cen, Letian Chen, Zihao Liu, Qun Lin, Xiaolin Fang, Herui Yao, Chang Gong
Abstract
Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.
Topics & Concepts
Breast cancerRNA-binding proteinDrug resistanceCancerRNAComputational biologyCancer therapyBiologyBioinformaticsMedicineCancer researchNeuroscienceInternal medicineGeneGeneticsRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer