Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans
James I. Bowen, Luoyi Wang, Matthew P. Crump, Christine L. Willis
Abstract
-selective intramolecular epoxide ring opening (IERO) of 4,5-epoxy-alcohols and their applications in natural product synthesis. In addition, the biosynthesis of THP-containing natural products which utilise IERO reactions are reviewed.
Topics & Concepts
ChemistryIntramolecular forceEpoxideNatural productRing (chemistry)EpoxyCombinatorial chemistryMoleculeStereochemistryOrganic chemistryCatalysisSynthetic Organic Chemistry MethodsMarine Sponges and Natural ProductsMarine Toxins and Detection Methods