adaptr: an R package for simulating and comparingadaptive clinical trials
Anders Granholm, Aksel Karl Georg Jensen, Theis Lange, Benjamin Skov Kaas‐Hansen
Abstract
The adaptr R package facilitates simulation and comparison of adaptive clinical trial designs using Bayesian statistical methods. The package supports a flexible number of arms, use of a common control arm, pre-specified and user-defined outcome-and posterior probability distribution-generating functions, fixed-and response-adaptive randomisation (RAR), various adaptation rules for arm dropping and stopping, calculation of trial design performance metrics, and visualisation of results. Simulations are relatively fast, can run in parallel, and can be reloaded from previous sessions.
Topics & Concepts
Computer scienceSample size determinationFlexibility (engineering)Bayesian probabilityScripting languageClinical trialR packageData miningStatisticsArtificial intelligenceMathematicsProgramming languageMedicinePathologyStatistical Methods in Clinical TrialsMeta-analysis and systematic reviewsAdvanced Causal Inference Techniques