MiR-200a and miR-200b restrain inflammation by targeting ORMDL3 to regulate the ERK/MMP-9 pathway in asthma
Xiaojun Duan, Xi Zhang, Lin‐Rui Li, Jiyan Zhang, Yanping Chen
Abstract
BACKGROUND: These findings suggest that miR-200a and miR-200b are required to regulate asthma inflammation. Reduction in miR-200a/200b promotes the development of asthma inflammation by targeting ORMDL3 to activate the ERK/MMP-9 pathway. Therefore, elevating miR-200a and miR-200b and decreasing ORMDL3 might be potential strategies for inhibition of the asthma process.
Topics & Concepts
MAPK/ERK pathwayGene silencingInflammationProinflammatory cytokineA549 cellCancer researchTumor necrosis factor alphaBiologyImmunologyMedicineKinaseCell biologyInternal medicineLungBiochemistryGeneCytokine Signaling Pathways and InteractionsIL-33, ST2, and ILC PathwaysAsthma and respiratory diseases