Cancer-associated fibroblast-released extracellular vesicles carrying miR-199a-5p induces the progression of gastric cancer through regulation of FKBP5-mediated AKT1/mTORC1 signaling pathway
Yan Wang, Tao Li, Lei Yang, Xunlei Zhang, Xiaoli Wang, SU Xiaoqin, Congfei Ji, Zhenxin Wang
Abstract
. Our findings point toward the critical role of CAFs-derived EVs carrying miR-199a-5p in gastric cancer progression.
Topics & Concepts
mTORC1Downregulation and upregulationBiologyCarcinogenesisCancer researchCancerCell biologyCancer cellMicrovesiclesPhosphorylationCancer-Associated FibroblastsSignal transductionmicroRNAPI3K/AKT/mTOR pathwayBiochemistryGeneticsGeneExtracellular vesicles in diseaseMicroRNA in disease regulationRNA modifications and cancer